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功能性蛋白質體實驗室
游佳融 教授 Prof. Chia Jung Yu
長庚大學學術能量集萃
我們的「功能性蛋白質體研究室」致力於結合功能性蛋白質體學、生化分生與細胞生物學策略，系統性解析
核質運輸、囊泡運輸與癌症發生之間的關鍵調控機制。我們特別關注細胞器如何透過特定蛋白質進行訊息交換，
並進一步釐清這些路徑在臨床疾病中的核心角色。在轉譯應用方面，我們運用多元癌症樣本建置大型蛋白質體資
料庫，發展可用於肺癌精準診斷與疾病追蹤的生物標誌，推動個人化醫療的發展。同時，我們深入探討核質運輸
蛋白 KPNA2 的癌化機制，揭示其在腫瘤進展與抗治療反應中的新功能，提供理解癌症病理的重要分子線索。在
細胞機制研究中，我們近期首次發現 Golgin‑97具有非典型的功能並展現抑癌特性，並參與整合細胞內外訊息、
免疫反應與囊泡運輸的複雜調控網路，此發現亦開啟探討高基氏體蛋白新功能與病理意義的研究方向。
我們研究室的核心特色包括：
• 以定量蛋白質體為核心技術，串聯基礎研究與臨床需求
• 深化細胞機制研究並拓展疾病應用
• 建立跨物種、跨細胞器的整合研究平台
我們期望藉由此跨領域研究平台，持續揭露細胞運輸系統的核心機制，並推動創新生物標誌與癌症治療策略
的發展。
Research directions and laboratory features
Our Functional Proteomics Laboratory integrates functional proteomics with biochemical,
molecular, and cell biology approaches to systematically define the regulatory mechanisms connecting
nucleocytoplasmic transport, vesicular trafficking, and cancer development. We investigate how
organelles communicate through specific proteins and clarify the roles of these pathways in human
disease. In translational research, we are building a comprehensive proteomics database from diverse
cancer samples to develop biomarkers for precise lung cancer diagnosis and monitoring, advancing
personalized medicine. We also study the oncogenic functions of the nucleocytoplasmic transport
protein KPNA2, revealing its roles in tumor progression and therapeutic resistance and providing new
molecular insights into cancer biology. In the mechanistic studies, we recently discovered that Golgin‑97
has non‑canonical functions and exhibits tumor‑suppressive activity. It operates within a complex
regulatory network that integrates intracellular and extracellular signaling, immune responses, and
vesicular trafficking. This finding opens new directions for exploring the functions and pathological
relevance of Golgi-associated proteins.
The core strengths of our laboratory include:
• Using quantitative proteomics as a platform to bridge basic and clinical research.
• Advancing mechanistic studies while expanding disease-focused applications.
• Establishing integrated research strategies across species and organelles.
Through this interdisciplinary platform, we aim to uncover key mechanisms of cellular transport
systems and drive the development of innovative biomarkers and cancer therapies.
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